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After administration of the 8-week clinical therapy, all detected acyl-carnitines had significant differences between the pre- and post-treatment groups with FDR q 1.0 with the OPLS-DA selection

Interestingly, researchers found that the plasma concentrations of carnitine and LAC were significantly higher in the CUMS-induced rat models than those in the control group, but there was no significant difference in the concentration of carnitine and LAC between the fluoxetine treatment group and the model group (31)