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For patients with multiple risk factors, shared decision-making should weigh potential benefits against theoretical risks, considering alternative pharmacological or surgical weight loss options where appropriate

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A prime candidate for Riegles first pilot study, he was also a skeptic

SGLT2 inhibitors therefore do not merely lower glycemia, but introduce a parallel energetic pathway that may buffer against progressive metabolic failure in vulnerable neural circuits

Stimulate faster metabolism and efficient energy conversion

doi:10.1212/CPJ.0000000000000043 While many studies have documented the short-term benefits of epidural steroid injections, the data on long-term effectiveness are less convincing