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In Tnf ARE mice, CD-like tissue inflammation develops gradually and microbiota-dependent due to loss of translational control of the pro-inflammatory cytokine tumor necrosis factor (Tnf) caused by a deletion of AU-rich (adenosin-uracil) elements (ARE) in the Tnf gene/ mRNA, resulting in Tnf overexpression (39)

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The FDA approved semaglutide 2.4 mg (Wegovy) for chronic weight management in adults with a BMI 30, or 27 with at least one weight-related comorbidity, in June 2021 [3]

Lagopati, I

Using GLP-1 agonists in high-risk individuals may delay or prevent the onset of obesity-related diseases

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