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Nature 504, 437440

In pre- and postnatal development studies in pregnant rats, empagliflozin was administered from gestation day 6 through to lactation day 20 (weaning) at up to 100 mg/kg/day (approximately 16-times the 25 mg maximum clinical dose) without maternal toxicity

Effects of some hepatomegalic agents on liver DNA content: Relationship to changes in liver blood flow

Epub 2021 Oct 11

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Patients commonly experience neurocognitive deficits such as reduced working memory, slower processing speed and impaired executive function, together with affective symptoms including depression, apathy and anxiety, which heighten the overall neuropsychiatric burden (7)