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The absolute risk in clinical trials is low , typically less than 0.5% , but the consequences of pancreatitis are serious enough that any severe abdominal pain radiating to the back should trigger immediate medical evaluation

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Without enough protein, you may lose muscle in addition to fat, which can negatively impact your metabolism, physical function and long-term health

To overcome the barriers and to improve the adherence, oral GLP-1 RAs were needed, but oral protein-based drug absorption is limited because of degradation in the stomach due to low pH, proteolytic enzyme activity, and limited permeability across the gastrointestinal (GI) epithelium

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