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GHK-Cu is unique in that it is a copper peptide complex rather than a purely synthetic compound, giving it a distinct mechanism of action rooted in endogenous biology

In particular, a variant of approximately 20 kDa originated by an alternative splicing is present in a rather constant 1:9 ratio, [10] while recently an additional variant of ~ 23-24 kDa has also been reported in post-exercise states at higher proportions

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However, bupropions activation of POMC also causes the release of -endorphin, an endogenous opioid that feeds back to inhibit POMC cells