Dysregulation of the de novo serine synthesis pathway impairs T-cell proliferation and their antitumor immune function ( + T-cell infiltration and is highly upregulated in breast cancer and papillary renal cell carcinoma ( In addition, activation of the serine synthesis pathway in glioblastoma attenuates the therapeutic efficacy of CAR-T cells, whereas PHGDH inhibition restores the antitumor activity of immune cells by enhancing STAT1 signaling ( Taken together, the de novo serine synthesis pathway (SSP) serves as a critical component of tumor metabolic reprogramming, driving malignant tumor progression through multi-dimensional regulatory mechanisms
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Biochem Biophys Res Commun 291:453457
Case reports and small trials show noticeable regrowth and nail thickening once levels are corrected
Peptide-conjugated oligonucleotides evoke long-lasting myotonic dystrophy correction in patient-derived cells and mice
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