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Present in human plasma, its concentration decreases with age

TREATMENT AREA Systemic (Targets the pituitary gland, metabolic system, and cellular repair mechanisms)

It binds to GHRH receptors on the pituitary to increase GH release in a pulse-like manner

Considerations Eating black licorice, blueberries, blood sausage or taking iron pills, activated charcoal, or medicines that contain bismuth (such as Pepto-Bismol), can also cause black stools

doi: 10.5582/irdr.2021.01055 43 CastoCPepeGLi PomiACoricaDAversaTWasniewskaM

The imbalance in polarization toward pro-inflammatory (M1) and anti-inflammatory (M2) phenotypes can lead to disturbances in intestinal immune homeostasis and inflammatory responses, which have a close association with IBD severity