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Key insight: Retatrutides glucagon-mediated increase in energy expenditure means the body is simultaneously eating less AND burning more a combination that may explain the superior efficacy signal seen in early trials

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There is enormous exuberance about starting GLP-1 drugs, but not nearly enough attention to what happens when people stop, said senior author Ziyad Al-Aly, M.D., a clinical epidemiologist at Washington University School of Medicine and chief of the Research and Development Service at the VA St

JAMA 326 , 926939 (2021)

Similarity Both MR and ER formulations are designed to provide pain relief for up to 8 hours