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Pharmacokinetic Parameters of DPP-4 Inhibitors Clinical Uses of DPP-4 Inhibitors Type 2 diabetes mellitus (monotherapy or combination with metformin, sulfonylureas, or SGLT2 inhibitors) Effective in elderly , overweight , or renal-compromised patients (e.g., linagliptin) Used when hypoglycemia and weight gain are concerns Adverse Effects of DPP-4 Inhibitors Nasopharyngitis , headache , upper respiratory symptoms Pancreatitis (rare but serious) Joint pain (FDA warning) Allergic reactions rash, urticaria Heart failure risk (with saxagliptin and alogliptin use cautiously in CHF) Comparative Analysis: DPP-4 Inhibitors vs GLP-1 Agonists Practice MCQs Q1

doi:10.1310/CH1N-YBNU-G3CU-JBXR 34

The study protocol was approved by the Research Ethics Committee of Ahvaz Jundishapur University of Medical Sciences (registration code: IR.AJUMS.REC.1401.416) and all the participants completed the written consent form

99% purity, HPLC-tested

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Astrocyte-neuron lactate transport is required for long-term memory formation