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Developing metabolomic clocks Following the idea that biomarkers of aging have to reflect not only inter-individual differences in mortality risk, but also the onset of age-related disease, we trained a penalized regression model to predict health status

5.5 Vitamin B12 Deficiency In controlled clinical trials of metformin of 29 weeks duration, a decrease to subnormal levels of previously normal serum vitamin B12 levels was observed in approximately 7% of patients

Diabetologia 2010;53:107683

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Oxidative damage to macromolecules in human Parkinson disease and the rotenone model

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