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15% identified as Hispanic or Latino ethnicity

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Cell 43 , 583590 (1985)

In murine models of ovarian cancer, melanoma, and glioblastoma, the IRF5/IKK NPs localized within tumor sites, where they reprogrammed TAMs, reduced M2 macrophage presence, and increased inflammatory cytokine production

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It has been reported that IGFBP-3 binds to a nuclear receptor, 9-cis retinoic acid receptor-alpha (RXR-), which interacts with peroxisome proliferator activated receptor-gamma (PPAR-), a nuclear protein involved in the regulation of glucose and lipid metabolism [175, 176]