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doi:10.1016/j.gene.2006.05.012

Chronic central infusions of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats

The damage may have been caused by a tumor or the surgery or radiation therapy that was performed to treat the tumor

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Because GH stimulates the liver to produce IGF-1, levels must be kept within a safe, physiological range to avoid potential risks related to cellular proliferation

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