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This novel method produced medicines that are capable of sustaining therapeutic drug levels for a minimum of 24 h, facilitating once-weekly administration for the majority of these drugs (Holst 2019)

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The clinical significance of these interactions will be detailed in the prescribing information when orforglipron is approved, and is an important consideration for the many patients with obesity or type 2 diabetes who take multiple concurrent medications

Below are known side effects of semaglutide, which are primarily GI related