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To further confirm the high quality and reliability of the data produced in each batch, all quality controls were ensured to occupy the same position in the multivariate analysis (19, 20)

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[24] [25] For patients with confirmed pathological hypercortisolism (Cushing's syndrome), definitive treatment depends on etiology and may include transsphenoidal surgery for pituitary adenomas, adrenalectomy for adrenal tumors, or medical therapy

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Within the tumor microenvironment, the IL-6/STAT3 pathway enhances tumor cell survival, proliferation, and invasiveness while simultaneously dampening antitumor immune responses