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The signs and symptoms of the deficiency may include anemia, the buildup of too much acid in the body (metabolic acidosis), frequent infections, and symptoms caused by problems in the brain including seizures, intellectual disability, and loss of coordination (ataxia)

doi: 10.1111/j.1365-2621.2005.tb11476.x

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Rigorous human pharmacokinetic data do not exist because no completed Phase 1-3 clinical trials have been published

Some compounds, such as 5-Amino-1MQ , can lose effectiveness when used continuously for longer than about 30 days