Any modifications to the FDA-recommended titration schedule should be directed by your healthcare provider
GLP-1 is an incretin hormone that responds to this increase in glucose by stimulating insulin release from the pancreas and signaling the brain to promote feelings of fullness
10.1074/jbc.274.48.33851 13 ButeauJ.RoduitR.SusiniS.PrentkiM
GLP-1 (glucagon-like peptide-1) is a naturally occurring incretin hormone secreted by enteroendocrine L-cells in the small intestine in response to food intake, where it signals satiety to the brain through hypothalamic receptor binding, slows gastric emptying to prolong the feeling of fullness, and modulates the release of insulin and glucagon in a glucose-dependent manner that helps stabilize post-meal blood sugar without the hypoglycemia risk associated with older drug classes
Injectable Prep and Technique Reconstitution is straightforward if you follow the steps: 50 mg vial plus 5 mL bacteriostatic water gives you 10 mg/mL 0.1 mL on an insulin syringe equals 1 mg (1,000 mcg) Use bacteriostatic water, not plain sterile water (bacteriostatic water contains a preservative that keeps the solution stable for multi-dose use) Swirl the vial gently
NICE guidance does not include probiotic recommendations for this population
