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327 However, in T-cell, the NAD + depletion by elevated CD38 expression increases the acetylation of EZH2 by in a SIRT1-dependent manner, leading to reduced cytotoxicity of CD8 T cell and enhanced inclination to infections in patients with systemic lupus erythematosus (SLE)

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Be aware of this and other potential side effects of alpha-lipoic aid use, which are discussed in the Concerns and Cautions section of our Alpha Lipoic Acid Review