3.1.4 Compound 968 Compound 968 is a specific allosteric inhibitor of GAC (Wang et al., 2010)
Reconstitute the 1mg lyophilized vial in 10mM hydrochloric acid (HCl) at a concentration of 0.5-1.0 mg/mL to ensure complete solubilization, as IGF-1 LR3's isoelectric point near pH 8.4 makes it poorly soluble in neutral buffers and prone to aggregation at physiological pH
There is no published, peer-reviewed randomized or controlled human trial of systemic GHK-Cu establishing efficacy or safety for any indication
Kim YJ, Park EJ, Lee SH, Silwal P, Kim JK, Yang JS, Whang J, Jang J, Kim JM, Jo EK
Influence of DEPMPO (20 mM) on resorufin formation in the presence of APEX2 (2 M) and Amplex Red (100 M), with or without GSH (1 mM) (right panel)
10.1016/j.eplepsyres.2011.05.005 70