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Many studies have confirmed oxidant-antioxidant imbalance in migraine, including NO, malondialdehyde (MDA), thiobarbituric acid reactive substances, thiol, catalase, superoxide dismutase, and glutathione imbalances (141, 142)

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Patches can provide steady, slow medication delivery, which might reduce side effects like nausea and eliminate the need for injections or strict pill-taking rules