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The first recombinant IGF-1 drugs have recently received US Food and Drug Administration (FDA) approval for the treatment of IGF-1 deficiency, and intense efforts for the expansion of its use in diseases such as sarcopenia, muscular dystrophy and amyotrophic lateral sclerosis are ongoing [6567]

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For instance, in an Australian study, approximately a third of patients with T2DM were found to have suboptimal adherence to their diabetes medication [63]