HRT may increase the risk of thromboembolic events, while semaglutide has been linked to increased heart rate
Injectable compounded runs $99 to $249 a month and has the strongest evidence base
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Beyond pancreatic beta-cell and metabolic research, sema has been investigated in models of cardiovascular disease, kidney function, liver steatosis, and neurodegeneration
Examples include: Sermorelin FDA-approved for diagnostic testing of growth hormone secretion (commonly used off-label for growth hormone optimization) Tesamorelin FDA-approved for reduction of excess abdominal fat in HIV-associated lipodystrophy Semaglutide (Ozempic, Wegovy) FDA-approved for type 2 diabetes and weight management Thymosin Alpha-1 FDA-approved in some countries, available via compounding in the US Category 2: Compoundable Peptides (Under FDA Discretion) These are peptides that are not FDA-approved drugs but can be compounded by licensed 503A or 503B pharmacies under specific circumstances, typically when theres a medical need and no FDA-approved alternative exists
And the drumbeat will continue unabated, with GLP-1 trials expected to be released this year examining their impact on knee osteoarthritis and obstructive sleep apnea
