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While reductions in ALT often correlate with decreased hepatic inflammation and fat content, it's important to recognise that these are surrogate markers and do not definitively confirm histological improvement

Both drugs have similar tolerability profiles at maximum tolerated doses, with tirzepatide clinical trials and semaglutide clinical trials showing similar GI-related symptoms

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In the GI tract, they are present on enteroendocrine cells that produce a range of gut hormones (including GLP-1, cholecystokinase [CCK], and peptide YY [PYY]) when the TAS2R is activated by a bitter substance

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