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These ROS deplete hepatic glutathione and drive oxidative stress in liver cells

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In recent years, different studies on CKD patients and animal models, such as mice, demonstrated that eryptosis, triggered by factors such as uremic toxins, inflammation, oxidative stress, and imbalances in calcium homeostasis, plays a fundamental role in the development and progression of renal anemia

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The findings of this study displayed a decline in the levels of matrix metalloproteinase-8 (MMP-8), reactive oxygen species, and reactive nitrogen species, hence furnishing antioxidant and anti-inflammatory effects