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This HO-CO pathway has been recently proposed to be involved in the defence against oxidative stress and the deleterious effects of NO, since it removes the cytotoxic free heme, and produces some molecules with antioxidant and anti-inflammatory effects, such as biliverdin and CO [8, 3840]

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In addition, the lungs are a major neutrophil reservoir, and circulating neutrophils retained in the lung microvasculature are known as the lung-marginated neutrophil pool [101]