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From these mutants only three displayed consistent and repeatable suppression of both carnitine related phenotypes

Consistently, knockout of LPCAT3 in lung epithelial cells conferred resistance to ferroptosis induced by the Ras-selective lethal compound 3 (RSL3), and reduced expression of ACSL4 or LPCAT3 diminished the availability of peroxidizable phospholipid substrates [39], thereby inhibiting ferroptosis and further emphasizing the critical role of PUFA metabolism in ferroptosis

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Using the dynamic recovery assay, we also found various conditions that resulted in isolated differences of the three parameters of the recovery curve of the matrix and IMS sensors as defined in Figure 5D and Supplementary Figure S3 ( sod2 strain