Also shown are the adverse clinical outcomes associated with elevated systemic TMAO levels in subjects, and enhanced cardiometabolic phenotypes observed with elevated TMAO levels in animal models (46, 12, 13, 1618)
The mechanism involves upregulation of matrix metalloproteinases (MMPs) and their inhibitors, which remodel collagen in a more organized way than unassisted healing
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doi: 10.1016/j.bbrc.2021.03.062 109 SleimanSFHenryJAl-HaddadREl HayekLAbou HaidarEStringerTet al
doi: 10.1164/rccm.201009-1393PP
Throughout the years, weight has proven challenging for many, with long-term success elusive
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