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A ClinicalTrials.gov-registered rehydration study confirmed that plain water consumption without electrolyte replacement dilutes plasma sodium concentration, suppresses the thirst signal, and increases renal urine output the physiological opposite of effective rehydration

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However, when DON-3-glucoside was administered to a cohort, approximately 4% of excreted DON was recovered as DON-3-glucoside (Vidal et al