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Applying cool compresses, wearing loose-fitting clothing, and using fragrance-free moisturizers can help

User experiences vary dramatically with some reporting maintained benefits months after stopping while others notice gradual decline toward pre-treatment baseline, creating confusion about optimal usage patterns including continuous application versus cycling protocols

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In contrast, the C-terminal half residues Val1268-His1271, which include the dibasic motif Lys1269-His1271, have consensus -propensity in the wild-type S tail but not the Thr1273Glu clientized mutant