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Semaglutide is a medication approved for type 2 diabetes and has shown weight loss for people with obesity

As a small molecule weighing approximately 529 Da, orforglipron binds to an allosteric pocket within the transmembrane domain of the GLP-1 receptor, stabilizing the active receptor conformation and driving downstream signaling through Gs protein coupling and cAMP accumulation

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"Someone like me could have a bottomless appetite for sweets, so I think those drugs can be good," she told The Times

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