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Chronic daily administration of cotadutide over 27 days in obese mice was associated with food intake reduction, decreased adiposity, improved fasting glucose, and increased energy expenditure

However, when adverse effects such as hypoglycemia and weight gain were taken into account, sitagliptin was better tolerated

It isnt a side effect of the medication itself but rather a cosmetic change that can occur when the face loses fat quickly

Tirzepatide activates both GLP-1 and GIP receptors, whereas semaglutide targets primarily GLP-1

13, e0194801 Veroniki AA, Seitidis G, Stewart L, Clarke M, Tudur-Smith C, Mavridis D, et al

Frontiers in Pharmacology, 14