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The bottom line for autoimmune patients considering tirzepatide After examining hundreds of studies, case reports, meta-analyses, and real-world observations, a clear picture emerges

Pharm Biol 50(8):10071012 Lee DU, Kang YJ, Park MK, Lee YS, Seo HG, Kim TS, Kim CH, Chang KC (2003) Effects of 13-alkyl-substituted berberine alkaloids on the expression of COX-II, TNF-alpha, iNOS, and IL-12 production in LPS-stimulated macrophages

10.1016/j.mce.2014.12.021 8 ChenJ.ZhaoH.MaX.ZhangY.LuS.WangY.et al (2017)

Polyethylene glycol (PEG) is a water-soluble inert polymer that reduces the renal clearance of the drug and prolongs the half-life, in addition to enhancing water solubility and preventing proteolysis

Clinical trials often focus on the most common or severe side effects

PubMed Link Lee DH, et al