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Oxidative phosphorylation modulators By competitively inhibiting long-chain 3-keto-CoA sulfatase, trimetazidine shifts myocardial metabolism from fatty acid -oxidation to glucose oxidation, thereby optimizing energy production during episodes of ischemia

Bigger picture: Estrogen is a signal in both men and women

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Efficacy: Studies suggest Tirzepatide may offer faster initial weight loss, but long-term data needs further investigation