& Pujol, J
Transplanting unmodified bone marrowderived cells into 70-day-old SOD1 G93A mice resulted in spinal cord engraftment but had no effect on mouse survival ([26, 138]
Figure 1A, B, and C Effect of Dihexa on spatial learning in the water maze
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AOD-9604 targets fat cells primarily through beta-3 adrenergic receptors, which are G-protein coupled receptors predominantly expressed in adipose tissue
To further characterize these interactions, we constructed a molecular interaction network (Figure 7C) revealed three functionally interconnected modules: ( Consistent with multi-omics findings, KEGG pathway analysis identified glutathione metabolism as the most significantly perturbed shared pathway (Figure 8A), exhibiting coordinated changes between upregulated antioxidant enzymes such as Gpx3 and Mgst1 alongside depleted glutathione derivatives, supporting redox imbalance as a key pathogenic feature
