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The adrenal cortex effectively produces sex hormones , albeit in small quantities

The most common diseases of iron overload are hereditary hemochromatosis (HH), caused by mutations in the HFE gene, and the more severe disease juvenile hemochromatosis (JH), caused by mutations in either hemojuvelin ( HJV ) [47] or hepcidin ( HAMP )

Appl Microbiol Biotechnol 98(24):1005310064

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Additionally, CAFs are capable of breaking down the ECM through the release of matrix metalloproteinases (MMPs) and the creation of novel matrix proteins involved in tumor penetration and angiogenesis [51,52,53]