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The guidelines also recommend using the medication in patients with a compelling need to minimize weight gain, patients prone to hypoglycemia, and patients who need a substantial A1C reduction [38]

Cyclooxygenase (COX) is a predominant enzyme in the PG synthetic pathway, which produces prostaglandin H 2 (PGH 2 ) from arachidonic acid (Shehzad et al., 2015)

Combination potentially superior to either alone

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Other proposed candidates for GSH efflux are hemichannels (connexins, CX), CFTR and RLIP76

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