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Even large trials/registries may lack power for small absolute risk increases Follow-up duration: Most studies provide 2-5 years observationsufficient for short-term safety, potentially insufficient for very long latency Histologic subtype adjudication often incomplete

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The dried sample was dissolved into 0.1% formic acid (18 L) and centrifuged (15,000 rpm, 10 min)

Significantly superior results were obtained in the group treated with the combination of acetyl L-carnitine and propionyl L-carnitine without sildenafil as compared to the group treated with sildenafil alone, in the tests recording nocturnal penile tumescence (Tables 5 and 10)