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Most significantly, its usually associated with heart disease (cardiomyopathy)

[68] found that peripheral nerves with enforced elevated levels of SAMe, were specially characterized by DNA hypermethylation at promoter and enhancer regions of several lipid synthesis genes, which contributed to the peripheral myelin defects

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This might initially seem counterintuitive, but controlled matrix degradation is essential for tissue remodeling and replacement of damaged structural proteins with newly synthesized, functional equivalents

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