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Statin use changes the gut microbiome in a way that reduces GLP-1 production.[ref] Statins are one of the top drugs prescribed each year

Pediatr Nephrol 30:13491360

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While these cryopreservation strategies provide options for the future ability to conceive genetic offspring, they do not prevent premature ovarian and endocrine failure which can lead to other long-term adverse outcomes including endocrine failure, osteoporosis, metabolic disease and neurocognitive disorders (Bruning et al, 1990

The classical complement pathway: activation and regulation of the first complement component