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445 Immunotherapeutic treatments have shown significant efficacy in TNBCs due to tumor immune infiltration, neoantigens caused by mutational burden and higher genomic instability, and high levels of immune markers such as PD-L1 and programmed cell death 1 (PD-1)

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123 In an uncontrolled pilot study in 40 women with PCOS, the combination of myo-inositol and lipoic acid decreased male hormone levels, improved menstrual regularity, and reduced unwanted hair growth and BMI without affecting glucose or insulin parameters

And third, both studies were done specifically in people with prediabetes, who already have disrupted blood sugar regulation

As we age, this layer can lose elasticity and strength, contributing to sagging skin and a less youthful appearance

Hooft, R