Symptoms that may be associated with MCAS include (6): Flushing Fatigue Dermatographism when light scratching of the skin leads to inflamed lines or welts Cognitive dysfunction Irritation of the eyes, nose, mouth, and/or throat Allergic type issues Shortness of breath Palpitations Nausea Gastroesophageal reflux Abdominal pain Diarrhea sometimes alternating with constipation Gynecological symptoms (interstitial cystitis, vulvovaginitis, heavy menstruation, menstrual pain) Fibromyalgia-type pain Headaches Dysautonomia Anxiety and mood disorders Metabolic and endocrine issues Persistent pain (especially nociplastic pain) Common triggers of mast cell activation include (3,9): Temperature: Heat, cold, or sudden temperature changes Emotional stress Physical exertion Fatigue Food or beverages, including alcohol Drugs (opioids, NSAIDs, antibiotics, and some local anesthetics) and contrast dyes Natural odors, chemical odors, perfumes, and scents Insect venoms Infections (viral, bacterial, or fungal) Mechanical irritation like friction or vibration Invasive procedures (general anesthesia, biopsy, endoscopy) Sun/sunlight What is anaphylaxis

Glutathione helps protect brain cells from oxidative damage, potentially slowing down cognitive decline and promoting better brain health
Shire US Inc
Advanced Funct materials (2024) 34:2313540
The blend's rationale is based on complementary mechanisms from separate studies of each compound
Cloning, expression, purification and characterization of recombinant glutathione-S-transferase from Xylella fastidiosa