Their marketing makes it seem easy and fast, and the prices are lower than brand-name versions of these medications
In SURMOUNT-5, gastrointestinal adverse events were the most common with both medications and were generally mild to moderate
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Advise patients that substantial or rapid weight loss can increase the risk of gallbladder disease, but that gallbladder disease may also occur in the absence of substantial or rapid weight loss
Contrave works on brain chemistry instead, produces a more modest 5 to 8 percent average, but comes without the GI side effects, injection requirement, or cost barriers that keep some patients away from GLP-1s
(February 17, 2025) Once-Weekly Semaglutide in Adults with Overweight or Obesity