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The trial product estimand evaluated the treatment effect while on treatment and without the use of rescue medication [60], providing a more direct evaluation of medication efficacy

7 No hypoglycemic events were recorded in the database, and no hypoglycemia-related doctor visits were reported during the 6-month follow-up period across both groups

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A positive control analysis was conducted to validate the genetic instruments for GLP-1R by verifying the association of genetic instruments from eQTLs with type 2 diabetes, given that GLP-1R agonists are FDA-approved for blood glucose and weight control

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