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Chronic exendin-4 treatment has shown anxiolytic and antidepressant-like effects in a Parkinson disease model induced by lipopolysaccharide and accompanied by alterations in dopaminergic signaling

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Our recommendation: Any patient using Melanotan II should undergo a baseline dermatological examination before starting and regular skin checks every 3 to 6 months during use

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[13] In summary, any medication that significantly alters pituitary-hypothalamic function or hormonal balance should be brought to the attention of the prescribing practitioner

It is worth noting that the changes observed in HbA1c, proinsulin levels, and indication of insulin resistance were more pronounced with tirzepatide than with dulaglutide