The main mechanism of action of antidepressants is to enhance the concentration of cAMP, thereby inducing alterations in the cAMP signaling cascade and its downstream target, pCREB BDNF ( The antidepressant effects of Yulangsan polysaccharide (YLSP) have been demonstrated in animal models of behavioral despair ( Poria cocos were found to enhance the levels of BNDF, 5-HT, 5-HIAA, DA, and NE in the hippocampus while significantly reducing Glu levels
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