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According to the FDA, these prescriptions are meant to be used along with a reduced-calorie diet and exercise to manage weight and reduce the risks of obesity-related conditions

62 The safety profile of semaglutide 2.4 mg was as expected for the GLP1RA class and was similar to that seen in other trials of subcutaneous semaglutide in individuals with type 2 diabetes

Tirzepatide activates both GLP-1 and GIP receptors

Around 1 to 2 pounds per week is considered a safe and sustainable rate of weight loss

For dosing protocols that minimize GI distress, see our retatrutide dosage calculator

But for now, most patients on tight budgets are facing difficult choices about giving up medicines that have helped them feel better or handing over the equivalent of a car payment every month to stay on GLP-1s