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Abbreviations AADC: Aromatic L-amino acid decarboxylase AAV: Adeno- associated virus AAV2: Adeno-associated virus serotype 2 ASO: Anti-sense oligonucleotide CNS: Central nervous system DaTscan: Dopamine transporter scan DBS: Deep brain stimulation DNA: Deoxyribonucleic acid ER: Endoplasmic reticulum FDA: Food and drug administration

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