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To further analyze the binding mode of COP1, we examined its interaction with Trib1 (PDB: 5IGQ) 43 , where COP1 residues from the top surface of the WD40 domain bind to Trib1 (residues V358-P359) through the bonding between Q356 sits in the binding pocket formed by S425, F645 and W517

Efficacy of synaptic inhibition depends on multiple, dynamically interacting mechanisms implicated in chloride homeostasis

It was first described in the scientific literature in 1993 and has since accumulated a substantial body of preclinical research across soft tissue, gastrointestinal and musculoskeletal contexts

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Separation was carried out using a 10 cm long C18 UPLC column with an ammonium acetate buffer (A) and methanol (B) as the mobile phase for gradient elution (575 % B in 10 min), at 40 C and 020 ml/min

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