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Supporting individuals who are taking GLP-1 medications requires a nuanced approach, Mitchell said

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Because many patients are prescribed both insulin and GLP-1 agonists, Geisler also examined how the two might interact

LY3437943 (Retatrutide): discovery to clinical proof of concept (triple GLP-1/GIP/glucagon agonist, preclinical mechanism) Nature Reviews Endocrinology (2024) Multi-receptor agonists for metabolic disease (mechanism of GLP-1/GIP/glucagon co-activation) Diabetes Care (2024) Incretin-based therapies: GLP-1, GIP, and glucagon receptor pharmacology (metabolic pathways, energy expenditure) NEJM (2023) Supplementary Material Jastreboff et al

Written informed consent to participate in this study was provided by the participants or their legal guardian/next of kin

Single to dual to triple agonism has produced sequentially larger signals