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patients should report right upper quadrant pain, fever, or jaundice Diabetic retinopathy complications : Rapid glycemic improvement may temporarily worsen retinopathy in susceptible patients Acute kidney injury : Usually secondary to dehydration from gastrointestinal side effects Hypoglycemia : Particularly when combined with insulin or sulfonylureas Altering the prescribed dose through cutting or splitting makes it impossible for healthcare providers to accurately assess whether adverse effects are dose-related and how to appropriately adjust therapy

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